The phase II clinical trial of rhNRG-1 initiated by Zensun (Shanghai) Sci & Tech Co., Ltd. is undergoing in USA. According to the current progress, the US based phase II clinical trial will be finished by 2013. And the end -of-phase II meeting with FDA will be held at early 2013 to review results of the US based phase II clinical trial, results of the China based phase I and II clinical trials, as well as results of survival study. At the meeting, Zensun will submit an application for phase III clinical trial.This clinical trial will be based on the modified design of the survival study which has been conducted in China.